All Projects

2022

Physiology-informed machine learning for precision phenotyping of heart failure with preserved ejection fraction

Scott Hummel, MD
Daniel Beard, PhD, MD
Yida Tang, MD, PhD

Gene Editing therapy for Usher Syndrome Type IIA

Yannis Paulus, MD
Dongshan Yang, PhD
Yang Li, PhD
Yun Feng, MD, PhD

Non-Invasive Preimplantation Genetic Testing for Aneuploidy (ni-PGT-A): Clinical Utility and Concordance with Human Blastocyst Regional Single Cell Sequencing (SCSeq)-PGT-A and Fertility Healthcare Provider Blastocyst Multi-Cell Trophectoderm Biopsy PGT-A

Gary Smith, PhD
Liying Yan, PhD
Zhiqiang Yan, PhD

Single-cell and spatial analyses of male germ cell development to advance understanding of idiopathic infertility in Chinese and American populations

Jun Li, PhD
Sue Hammoud, PhD
Jie Qiao, MD, PhD
Peng Yuan, PhD

Discover novel therapeutic targets for aortic aneurysm and dissection through data mining and experimental models

Jifeng Zhang, PhD
Lemin Zheng, PhD
Wei Li, MD

2021

Clinical Validation of a Patient-specific Pharmacogenomics Assay for Enhanced Treatment Response in Bipolar Disorder-1 (BPD-1) Patients

Brian Athey, PhD
Lin Lu, MD, PhD

Optimization of Limb Salvage Strategy for Critical Limb Ischemia Using Quantitative Vascular Imaging Biomarkers

J. Brian Fowlkes, PhD
Xiaofeng Yin, MD, PhD

Single Cell RNA Sequencing to identify transcriptional signatures of failure to repair after Acute Kidney Injury in patients with and without Covid‐19 disease

Matthias Kretzler, MD
Li Yang, MD

The role of endoplasmic reticulum associated degradation (ERAD) in antigen presentation and immune evasion of multiple myeloma cells

Qing Li, MD, PhD
Yujun Dong, MD

Malic Enzyme Dependence is a Therapeutic Vulnerability in Pancreatic and Gastric Cancers

Costas Lyssiotis, PhD
Shigang Ding, MD

Assessing Genomic and Environmental Drivers of Depression in Training Physicians across China and the US

Srijan Sen, MD, PhD
Hongqiang Sun, MD, PhD

Metabolic and epigenetic regulation in cell based heart repair

Zhong Wang, PhD
Ming Cui, MD, PhD

Role of Exosome Signaling in Cancer Cell Dedifferentiation and Chemo-Resistance 

Max Wicha, MD
Ming Luo, PhD
Wei Wei, MD

Nanobubble water combined with apyrase as root canal irrigant inhibits biofilm and virulence of Enterococcus faecalis 

Chuanwu Xi, PhD
Yanmei Dong, DDS, PhD

Decipher Immune Signatures and Therapeutic Response in Chinese and American Multiple Myeloma Patients

Christine Ye, MD
Xiao-Jun Huang, MD

2019

Determining genetic and microbiome effects on non-alcoholic fatty liver disease and its medical complications in a Chinese population

Elizabeth Speliotes, MD, PhD, MPH
Linong Ji, MD

LILRA3 as a novel regulator of thrombioinflammation in antiphospholipid syndrome (APS)

Jason Knight, MD, PhD
Jianping Guo, MD, PhD

Molecular signatures underlying the progression of intestinal meaplasia: a multi-omics approach

Andrea Tosisco, MD
John Kao, MD
Wen-Qing Li, PhD

Gaining insight into retinal cell death: rational drug development through vitreous proteomic analysis

David Zacks, MD, PhD
Liu Yang, MD, PhD

Citrullinated Histone H3: A Mediator and Biomarker of Sepsis-induced Acute Lung Injury

Yongqing Li, MD, PhD
Tianbing Wang, MD

Michigan-Peking Cancer Biomarker Collaborative

Arul Chinnaiyan, MD, PhD
Yuxin Yin, MD, PhD

EMERALD-HF: Evaluation of MinERalocorticoid antagonists in ALdehyde dehydrogenase type 2 Deficiency

Bertram Pitt, MD
Porama Thanaporn, MD
Wei Gao, MD

New Strategy to Identify, Validate, and Eliminate Heterogeneity for Personalized Cancer Therapy of Breast Cancer or Liver Cancer

Duxin Sun, PhD
Ning Zhang, PhD

Deferoxamine in the Treatment of Aneurysmal Subarachnoid Hemmorrhage (DISH)

Aditya Pandey, MD
Yining Huang, MD

Building a Learning Health System for Kidney Disease through Meaningful Use of Electronic Health Record Data in Yinzhou China

Charles Friedman, PhD
Luxia Zhang, MD

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