Development and Validation of MyProstateScore 2.0 to Detect Clinically Significant Prostate Cancer
MedRxiv
UM PI: Arul Chinnaiyan

Spatiotemporal Local and Abscopal Cell Death and Immune Responses to Histotripsy Focused Ultrasound Tumor Ablation
Frontiers in Immunology
UM PI: Clifford Cho

Current Landscape of Genomic Biomarkers in Clear Cell Renal Cell Carcinoma
European Oncology
UM PI: Ganesh Palapattu

Galectin-3-centered Paracrine Network Mediates Cardiac Inflammation and Fibrosis Upon β-adrenergic Insult
Science China. Life Sciences
UM PI: Marschall Runge
PKUHSC PI: Youyi Zhang

Role of Peptidylarginine Deiminase and Neutrophil Extracellular Traps in Injuries: Future Novel Diagnostics and Therapeutic Targets
Shock
UM PI: Yongqing Li

Metformin Directly Binds to MMP-9 to Improve Plaque Stability
Journal of Cardiovascular Science and Disease
PKUHSC PI: Youyi Zhang

The Role of the Inflammasome in Heart Failure
Frontiers in Physiology
PKUHSC PI: Youyi Zhang

Editorial: Targeting Protein Post-Translational Modifications (PTMs) for Diagnosis and Treatment of Sepsis
Frontiers in Immunology
UM PI: Yongqing Li
PKUHSC PI: Panpan Chang

Soluble LILRA3 is Aberrantly Expressed in Antiphospholipid Syndrome (APS) and is a Potential Marker of Thrombotic APS
Rheumatology
UM PI: Jason Knight
PKUHSC PI: Jianping Guo

Impact of Histotripsy on Development of Intrahepatic Metastases in a Rodent Liver Tumor Model
Cancers
UM PI: Clifford Cho

Prediction of Pathogenic Factors in Dysbiotic Gut Microbiomes of Colorectal Cancer Patients Using Reverse Microbiomics
Frontiers in Oncology
UM PI: Oliver He

Systemic Investigation of the Microbiome-host Interactions in H. pylori-associated Gastric Cancer Patients
Molecular & Cellular Proteomics
PKUHSC PI: Jianmin Wu

Multi-Scalar Data Integration Links Glomerular Angiopoietin-Tie Signaling Pathway Activation With Progression of Diabetic Kidney Disease
Diabetes
UM PI: Wenjun Ju
PKUHSC PI: Min Chen

Molecular Characterization of Clear Cell Renal Cell Carcinoma Reveals Prognostic Significance of Epithelial-mesenchymal Transition Gene Expression Signature
European Urology Oncology
UM PI: Ganesh Palapattu

Clinical Outcomes in a Cohort of Patients with Cutaneous T-cell Lymphoma and COVID-19
JAAD International
UM PI: Trilokraj Tejasvi

PEG10 Amplification at 7q21.3 Potentiates Large-cell Transformation in Cutaneous T-cell Lymphoma
Blood
UM PIs: Trilokraj Tejasvi and Alex Tsoi
PKUHSC PI: Yang Wang

Improved diagnostic prediction of the pathogenicity bloodstream isolates of Staphylococcus epidermidis
PLoS One
U-M PI: J. Scott Van Epps

An Asian-specific MPL genetic variant alters JAK-STAT signaling and influences platelet count in the population
Human Molecular Genetics
UM PI: Santhi Ganesh
PKUHSC PI: Yan Zhang

Hemoglobin and erythrocyte count are independently and positively associated with arterial stiffness in a community-based study
Journal of Human Hypertension
UM PI: Santhi Ganesh
PKUHSC PI: Yan Zhang

Epidemiologic and Genetic Associations of Erythropoietin With Blood Pressure, Hypertension, and Coronary Artery Disease
Hypertension
UM PI: Santhi Ganesh
PKUHSC PI: Yan Zhang

Exome-wide association study of plasma lipids in >300,000 individuals
Nature Genetics
UM PI: Cristen Willer
PKUHSC PI: Ming Zu

Annexin A1 alleviates kidney injury by promoting the resolution of inflammation in diabetic nephropathy
Kidney International
U-M PI: Wenjun Ju & Matthias Kretzler
PKUHSC PI: Min Chen

The Prevalence of Diabetic Microvascular Complications in China and the United States
Current Diabetes Reports
U-M PI: Rodica Busui
PKUHSC PI: Luxia Zhang

Associations of Genetic Variants Contributing to Gut Microbiota Composition in Immunoglobin A Nephropathy
mSystems
PKUHSC PI: Hong Zhang

Potential Roles of Oral Microbiota in the Pathogenesis of Immunoglobin A Nephropathy
Frontiers in Cellular and Infection Microbiology
PKUHSC PI: Hong Zhang

Five Novel Loci Are Implicated in Predisposing to IgA Nephropathy by an Exome-Wide Association Study of Han Chinese
Clinical Journal of the American Society of Nephrology
U-M PI: Christine Berthier
PKUHSC PI: Hong Zhang

Reverse Microbiomics: a new reverse dysbiosis analysis strategy and its usage in prediction of autoantigens and virulent factors in dysbiotic gut microbiomes from rheumatoid arthritis patients
Frontiers in Microbiology
U-M PI: Oliver He

PINA 3.0: mining cancer interactome
Nucleic Acids Research
PKUHSC PI: Jianmin Wu

Disclosure of clinically actionable genetic variants to thoracic aortic dissection biobank participants
BMC Medical Genomics
U-M PI: Cristen Willer

Ethical Perspectives of Chinese and United States Physicians within a Research Collaborative
Accountability in Research
U-M PIs: Michael Geisser, Joseph Kolars, & Raymond Hutchinson
PKUHSC PI: Yali Cong

Advancing science and education through a novel collaboration platform between the University of Michigan and Peking University Health Science Center
FASEB BioAdvances
U-M PI: Joseph Kolars
PKUHSC PI: Qimin Zhan

Rapid single-molecule digital detection of protein biomarkers for continuous monitoring of systemic immune disorders
Blood
U-M PI: Yongqing Li

Ontological modeling and analysis of experimentally or clinically verified drugs against coronavirus infection
Scientific Data
U-M PI: Oliver He

Albuminuria and retinal vessel density in diabetes without diabetic retinopathy: the Kailuan Eye Study. Acta Ophthalmol. 2020.
Acta Ophthalmolgica
PKUHSC PI: Luxia Zhang

Immunoproteasome in IgA Nephropathy: State-of-Art and Future Perspectives
International Journal of Biological Sciences
PKUHSC PI: Hong Zhang

Perspectives on how mucosal immune responses, infections, and gut microbiome shape IgA nephropathy, and future therapies
Theranostics
PKUHSC PI: Hong Zhang

CVCDAP: an integrated platform for molecular and clinical analysis of cancer virtual cohorts
Nucleic Acids Research
PKUHSC PI: Jianmin Wu

Non-thermal histotripsy tumor ablation promotes abscopal immune responses that enhance cancer immunotherapy
Journal for Immunotherapy of Cancer
U-M PI: Clifford Cho

Aortic progression and reintervention in patients with pathogenic variants after a thoracic aortic dissection
Journal of Thoracic and Cardiovascular Surgery
U-M PI: Cristen Willer

Soluble urokinase-type plasminogen activator receptor and incident end-stage renal disease in Chinese patients with chronic kidney disease
Nephrology Dialysis Transplantation
PKUHSC PI: Minghui Zhao

Peptidylarginine deiminase 2 has potential as both a biomarker and therapeutic target of sepsis
JCI Insight
U-M PIs: Yongqing Li & Hasan Alam

Associations of Urinary Epidermal Growth Factor and Monocyte Chemotactic Protein-1 with Kidney Involvement in Patients with Diabetic Kidney Disease
Nephrology Dialysis Transplantation
PKUHSC PIs: Min Chen, Minghui Zhao & Luxia Zhang

HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation
Science
U-M PIs: Yongqing Li & Hasan Alam

PAD2 Mediates Caspase-1 Associated Lethality in Pseudomonas Aeruginosa Pneumonia Induced Sepsis
Journal of Infectious Disease
U-M PIs: Yongqing Li & Hasan Alam

Inhibition of PAD2 Improves Survival in a Mouse Model of Lethal LPS-Induced Endotoxic Shock
Inflammation
U-M PIs: Yongqing Li & Hasan Alam

Hemoglobin and erythrocyte count are independently and positively associated with arterial stiffness in a community-based study
Journal of Human Hypertension
U-M PI: Santhi Ganesh
PKUHSC PI: Yan Zhang

Clopidogrel Resistance in a Murine Model of Diet-Induced Obesity Is Mediated by the Interleukin-1 Receptor and Overcome With DT-678
Arteriosclerosis, Thrombosis, and Vascular Biology
U-M PIs: Daniel Eitzman, Haoming Zhang & Eugene Chen
PKUHSC PI: Jianping Li

Podocytes and autophagy: A potential therapeutic target in lupus nephritis
Autophagy
PKUHSC PI: Hong Zhang

Autophagy and immunological aberrations in systemic lupus erythematosus
European Journal of Immunology
PKUHSC PI: Hong Zhang

Disruption of Histidine and Energy Homeostasis in Chronic Obstructive Pulmonary Disease
International Journal of Chronic Obstructive Pulmonary Disease
U-M PI: Theodore Standiford
PKUHSC PI: Bei He

Serum amino acid concentrations and clinical outcomes in smokers: SPIROMICS metabolomics study
Scientific Reports
U-M PI: Theodore Standiford
PKUHSC PI: Bei He

Training Pathways to Working as a General Practitioner in China
Family Medicine
U-M PI: Michael Fetters

Survey of Nonalcoholic Fatty Liver Disease Knowledge, Nutrition, and Physical Activity Patterns Among the General Public in Beijing, China
Digestive Diseases and Sciences
U-M PI: Anna Lok
PKUHSC PI: Lai Wei

Awareness and Knowledge of Nonalcoholic Fatty Liver Disease Among Office Employees in Beijing, China
Digestive Diseases and Sciences
U-M PI: Anna Lok
PKUHSC PI: Lai Wei

Accumulation, Liver Fibrosis, and Metabolic Abnormalities in Chinese Patients With Moderate/Severe Versus Mild Hepatic Steatosis
Hepatology Communication
U-M PI: Anna Lok
PKUHSC PI: Lai Wei

Sorafenib Encapsulated in Nanocarrier Functionalized With glypican-3 Specific Peptide for Targeted Therapy of Hepatocellular Carcinoma
Colloids and Surfaces B: Biointerfaces
U-M PI: Thomas Wang
PKUHSC PI: Jiye Zhu

Peptidylarginine Deiminase 2 Knockout Improves Survival in Hemorrhagic Shock
Shock
U-M PIs: Hasan Alam, Yongqing Li & Thomas Wang
PKUHSC PIs: Tianbing Wang & Baoguo Jiang

OHMI: the ontology of host-microbiome interactions
Journal of Biomedical Semantics
U-M PI: Oliver He
PKUHSC PI: Jianmin Wu

Increased mitochondrial NADPH oxidase 4 (NOX4) expression in aging is a causative factor in aortic stiffening
Redox Biology
U-M PI: Marschall Runge
PKUHSC PI: You Yi Zhang

Clinical Implications of Identifying Pathogenic Variants in Individuals With Thoracic Aortic Dissection
Circulation: Genomic and Precision Medicine
U-M PI: Cristen Willer

HDAC inhibitor valproic acid protects heart function through Foxm1 pathway after acute myocardial infarction.
EBioMedicine
U-M PIs: Zhong Wang, Hasan Alam, Yongqing Li & Eugene Chen

Effects of medication-assisted treatment on mortality among opioids users: a systematic review and meta-analysis
Molecular Psychiatry
U-M PIs: Fred Blow & Mark Ilgen
PKUHSC PI: Lin Lu

The rising crisis of illicit fentanyl use, overdose, and potential therapeutic strategies
Translational Psychiatry
PKUHSC PI: Lin Lu

Profile of psychiatric symptoms in methamphetamine users in China: Greater risk of psychiatric symptoms with a longer duration of use
Psychiatry Research
PKUHSC PI: Lin Lu

Epidemiological characteristics and risk factors of methamphetamine-associated psychotic symptoms
Frontiers in Psychiatry
PKUHSC PI: Lin Lu

Poly-drug use of prescription medicine among people with opioid use disorder in China: A systematic review and meta-analysis
Substance Use and Misuse
PKUHSC PI: Lin Lu

Serum uromodulin and progression of kidney disease in patients with chronic kidney disease
Journal of Translational Medicine
PKUHSC PI: Minghui Zhao

Increased autophagy is cytoprotective against podocyte injury induced by antibody and interferon-alpha in lupus nephritis
Annals of the Rheumatic Diseases
PKUHSC PI: Hong Zhang

Exploring the Role of Autophagy-Related Gene 5 (ATG5) Yields Important Insights Into Autophagy in Autoimmune/Autoinflammatory Diseases
Frontiers in Immunology
PKUHSC PI: Hong Zhang

Mortality risk of chronic kidney disease: A comparison between the adult populations in urban China and the United States
PLoS One
U-M PI: Jennifer Bragg-Gresham

Prevalence and Risk Factors for CKD: A Comparison Between the Adult Populations in China and the United States.
Kidney International Reports
U-M PI: Jennifer Bragg-Gresham
PKUHSC PI: Ming-hui Zhao

Variation in doses and duration of particulate matter exposure in bronchial epithelial cells results in upregulation of different genes associated with airway disorders
Toxicology In Vitro
U-M PI: Steven Huang
PKUHSC PI: Yahong Chen

Multiregional sequencing reveal genomic alterations and clonal dynamics in primary malignant melanoma of the esophagus
Cancer Research
U-M PI: Jun Li
PKUHSC PI: Yang Ke

Inhibition of Peptidylarginine Deiminase Alleviates LPS-induced Pulmonary Dysfunction and Improves Survival in a Mouse Model of Lethal Endotoxemia
European Journal of Pharmacology
U-M PIs: Hasan Alam & Yongqing Li

Relationship between the duration of methamphetamine use and psychotic symptoms: A two-year prospective cohort study
Drug and Alcohol Dependence
U-M PI: Fred Blow

Myeloperoxidase mediated HDL oxidation and HDL proteome changes do not contribute to dysfunctional HDL in Chinese subjects with coronary artery disease
PLoS One
U-M PI: Eugene Chen
PKUHSC PI: Guisong Wang

Effect of Ambient Fine Particulate Matter Air Pollution and Colder Outdoor Temperatures on High-Density Lipoprotein Function
American Journal of Cardiology
U-M PI: Robert Brook

Short-Term Blood Pressure Responses to Ambient Fine Particulate Matter Exposures at the Extremes of Global Air Pollution Concentrations
American Journal of Hypertension
U-M PI: Robert Brook
PKUHSC PI: Jianping Li

Structural basis for the antiarrhythmic blockade of a potassium channel with a small molecule
FASEB Journal
U-M PI: Jose Jalife

Minocycline effects on intracerebral hemorrhage-induced iron overload in aged rats: brain iron quantification with MRI
Stroke
U-M PI: Guohua Xi

Early Hemolysis Within Human Intracerebral Hematomas: an MRI Study
Translational Stroke Research
U-M PI: Guohua Xi

Urinary Epidermal Growth Factor Predicts Renal Prognosis in Antineutrophil Cytoplasmic Antibody-associated Vasculitis
Annals of Rheumatic Diseases
U-M PI: Wenjun Ju
PKUHSC PI: Ming-hui Zhao

Pattern and related factors of cognitive impairment among chronic methamphetamine users
American Journal of Addiction
PKUHSC PI: Lin Lu

Chinese herbal medicine for the treatment of drug addiction
International Review of Neurobiology
PKUHSC PI: Lin Lu

Accelerated podocyte detachment and progressive podocyte loss from glomeruli with age in Alport Syndrome
Kidney International
U-M PI: Roger Wiggins
PKUHSC PI: Jie Ding

Collaboration platforms in China for translational and clinical research: the partnership between Peking University Health Science Center and the University of Michigan Medical School
Academic Medicine
U-M PI: Joseph Kolars
PKUHSC PI: Weigang Fang

Education Improves Patient Knowledge and Acceptance on Antiviral Therapy of Hepatitis C in Rural China
Chinese Medical Journal
U-M PI: Anna Lok
PKUHSC PI: Lai Wei

Risk Assessment of Hepatocellular Carcinoma in Patients with Hepatitis C in China and the USA
Digestive Disease and Sciences
U-M PI: Anna Lok
PKUHSC PI: Lai Wei

Temporal changes in the modes of hepatitis C virus transmission in the USA and Northern China
Digestive Disease and Sciences
U-M PI: Anna Lok
PKUHSC PI: Lai Wei

Mutation landscape and intratumor heterogeneity of two MANECs of the esophagus revealed by multi-region sequencing
Oncotarget
U-M PI: Jun Li
PKUHSC PI: Yang Ke

The higher prevalence of truncal obesity and diabetes in American than Chinese patients with chronic hepatitis C might contribute to more rapid progression to advanced liver disease
Alimentary Pharmacology & Therapeutics
U-M PI: Anna Lok
PKUHSC PI: Lai Wei

CitH3: a reliable blood biomarker for diagnosis and treatment of endotoxic shock
Scientific Reports
U-M PI: Hasan Alam
PKUHSC PI: Baoguo Jiang

Personal-level exposure to environmental temperature is a superior predictor of edothelialdpendent vasodilatation than outdoor-ambient level
Journal of the American Society of Hypertension
U-M PI: Robert Brook
PKUHSC PI: Jianping Li

Transplantation of multipotent Isl1+ cardiac progenitor cells preserves infarcted heart function in mice
American Journal of Translational Research
U-M PI: Zhong Wang
PKUHSC PI: Hongkuei Deng

Air Pollution and Cardiometabolic Disease: An Update and Call for Clinical Trials
American Journal of Hypertension
U-M PI: Robert Brook
PKUHSC PI: Jianping Li

Transplantation of Isl1+ Cardiac Progenitor Cells in Small Intestinal Submucosa Improves Infarcted Heart Function
Stem Cell Research Therapy
U-M PI: Zhong Wang

CD163 expression in neurons after experimental intracerebral hemorrhage
Stroke
U-M PI: Guohua Xi
PKUHSC PI: Yining Huang

Eplerenone Reduces Atrial, Fibrillation Burden Without Preventing Atrial Electrical Remodeling
Journal of the American College of Cardiology
U-M PI: Jose Jalife

“Stressed” About Air Pollution: Time for Personal Action
Circulation
U-M PI: Robert Brook
PKUHSC PI: Jianping Li

Exome chip meta-analysis identifies novel loci and East Asian–specific coding variants contributing to lipid levels and coronary artery disease
Nature Genetics
U-M PI: Christen Willer
PKUHSC PI: Ming-Hsu

Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency
Cell
U-M PI: Zhong Wang
PKUHSC PI: Hongkuei Deng

In vivo photoacoustic tomography of EGFR overexpressed in hepatocellular carcinoma mouse xenograft
Photoacoustics
U-M PI: Thomas Wang
PKUHSC PI: Jiye Zhu

A Comparative Study of Liver Disease Care in the USA and Urban and Rural China
Digestive Disease and Sciences
U-M PI: Anna Lok
PKUHSC PI: Lai Wei

In vivo fluorescence imaging of hepatocellular carcinoma xenograft using near-infrared labeled epidermal growth factor receptor (EGFR)
Biomedical Optic Express
U-M PI: Thomas Wang
PKUHSC PI: Jiye Zhu

Survey of hepatitis B knowledge and stigma among chronically infected patients and uninfected persons in Beijing, China.
Liver International
U-M PI: Anna Lok
PKUHSC PI: Lai Wei

Protective effect of Cl-amidine against CLP-induced lethal septic shock in mice
Scientific Reports
U-M PI: Hasan Alam
PKUHSC PI: Baoguo Jiang

Quantitative analysis of MR imaging to assess treatment response for patients with multiple myeloma by using dynamic intensity entropy transformation: a preliminary study
Radiology
U-M PI: Qian Dong
PKUHSC PI: Jin Lu

Galectin-3 Regulates Atrial Fibrillation Remodeling and Predicts Catheter Ablation Outcomes. JACC: Basic to Translational Science
JACC: Basic to Translational Science
U-M PI: Jose Jalife

Improving cardiac reprogramming for heart regeneration
Current Opinion in Organ Transplantation
U-M PI: Zhong Wang
PKUHSC PI: Hongkuei Deng

Targeting Mll1 H3K4 methyltransferase activity to guide cardiac lineage specific reprogramming of fibroblasts
Cell Discovery
U-M PI: Zhong Wang
PKUHSC PI: Hongkuei Deng

Atrial Fibrillation Susceptibility in Obesity: An Excess Adiposity and Fibrosis Complicity?
Circulation Research
U-M PI: Jose Jalife

Meta-analysis of rare and common exome chip variants identifies S1PR4 and other loci influencing blood cell traits
Nature Genetics
U-M PI: Santhi Ganesh
PKUHSC PI: Yan Zhang 2016

NEPTUNE and PKU-IgAN Consortium (2015) Tissue transcriptome-driven identification of epidermal growth factor as a chronic kidney disease biomarker
Science Translational Medicine
U-M PI: Mattias Kretzler
PKUHSC PI: Minghuei Zhao