Lymph nodes are involved in antigen presentation, T cell priming and activation, which are essential for initiating anti-tumor immunity. However, sentinel LNs (or tumor draining LNs) are one of the most common sites of tumor metastasis. The immunological significance of tumor metastatic LNs in the tumor immune responses remains elusive. Furthermore, it remains an open question whether surgical removal of metastatic LNs is an effective approach. The overall goal of this proposal is to understand, and potentially resolve this immunological and clinical paradox.  Read more about the project.