The Role of Hematopoietic Factors in Atherosclerotic Vascular Diseases

JI program: Cardiovascular


Cardiovascular disease (CVD) is the leading cause of death globally. Elevated blood pressure (BP), or hypertension (HTN), is a major and heritable risk factor for CVD. Genetic associations with BP/HTN found to date explain little of the variance of BP in the general population, and the mechanisms are largely unknown. This project will investigate the impact of hematologic traits on BP and HTN. The team hypothesizes that genetic variants underlying the joint associations between hematologic and BP traits can be identified using an unbiased genetic association study, and that these findings extend to CVD outcomes.


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